A Variable Polyglutamine Repeat Affects Subcellular Localization and Regulatory Activity of a Populus ANGUSTIFOLIA Protein.
Identifieur interne : 001083 ( Main/Exploration ); précédent : 001082; suivant : 001084A Variable Polyglutamine Repeat Affects Subcellular Localization and Regulatory Activity of a Populus ANGUSTIFOLIA Protein.
Auteurs : Anthony C. Bryan [États-Unis] ; Jin Zhang [États-Unis] ; Jianjun Guo [États-Unis] ; Priya Ranjan [États-Unis] ; Vasanth Singan [États-Unis] ; Kerrie Barry [États-Unis] ; Jeremy Schmutz [États-Unis] ; Deborah Weighill [États-Unis] ; Daniel Jacobson [États-Unis] ; Sara Jawdy [États-Unis] ; Gerald A. Tuskan [États-Unis] ; Jin-Gui Chen [États-Unis] ; Wellington Muchero [États-Unis]Source :
- G3 (Bethesda, Md.) [ 2160-1836 ] ; 2018.
Descripteurs français
- KwdFr :
- Allèles (MeSH), Noyau de la cellule (métabolisme), Peptides (composition chimique), Populus (génétique), Populus (métabolisme), Protéines de liaison à l'ADN (composition chimique), Protéines de liaison à l'ADN (métabolisme), Protéines végétales (composition chimique), Protéines végétales (métabolisme), Signaux de triage des protéines (MeSH), Transport nucléaire actif (MeSH).
- MESH :
- composition chimique : Peptides, Protéines de liaison à l'ADN, Protéines végétales.
- génétique : Populus.
- métabolisme : Noyau de la cellule, Populus, Protéines de liaison à l'ADN, Protéines végétales.
- Allèles, Signaux de triage des protéines, Transport nucléaire actif.
English descriptors
- KwdEn :
- Active Transport, Cell Nucleus (MeSH), Alleles (MeSH), Cell Nucleus (metabolism), DNA-Binding Proteins (chemistry), DNA-Binding Proteins (metabolism), Peptides (chemistry), Plant Proteins (chemistry), Plant Proteins (metabolism), Populus (genetics), Populus (metabolism), Protein Sorting Signals (MeSH).
- MESH :
- chemical , chemistry : DNA-Binding Proteins, Peptides, Plant Proteins.
- genetics : Populus.
- metabolism : Cell Nucleus, DNA-Binding Proteins, Plant Proteins, Populus.
- Active Transport, Cell Nucleus, Alleles, Protein Sorting Signals.
Abstract
Polyglutamine (polyQ) stretches have been reported to occur in proteins across many organisms including animals, fungi and plants. Expansion of these repeats has attracted much attention due their associations with numerous human diseases including Huntington's and other neurological maladies. This suggests that the relative length of polyQ stretches is an important modulator of their function. Here, we report the identification of a Populus C-terminus binding protein (CtBP) ANGUSTIFOLIA (PtAN1) which contains a polyQ stretch whose functional relevance had not been established. Analysis of 917 resequenced Populus trichocarpa genotypes revealed three allelic variants at this locus encoding 11-, 13- and 15-glutamine residues. Transient expression assays using Populus leaf mesophyll protoplasts revealed that the 11Q variant exhibited strong nuclear localization whereas the 15Q variant was only found in the cytosol, with the 13Q variant exhibiting localization in both subcellular compartments. We assessed functional implications by evaluating expression changes of putative PtAN1 targets in response to overexpression of the three allelic variants and observed allele-specific differences in expression levels of putative targets. Our results provide evidence that variation in polyQ length modulates PtAN1 function by altering subcellular localization.
DOI: 10.1534/g3.118.200188
PubMed: 29884614
PubMed Central: PMC6071607
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A Variable Polyglutamine Repeat Affects Subcellular Localization and Regulatory Activity of a <i>Populus</i> ANGUSTIFOLIA Protein.</title><author><name sortKey="Bryan, Anthony C" sort="Bryan, Anthony C" uniqKey="Bryan A" first="Anthony C" last="Bryan">Anthony C. Bryan</name><affiliation wicri:level="2"><nlm:affiliation>Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge, TN 37831.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge</wicri:cityArea></affiliation></author><author><name sortKey="Zhang, Jin" sort="Zhang, Jin" uniqKey="Zhang J" first="Jin" last="Zhang">Jin Zhang</name><affiliation wicri:level="2"><nlm:affiliation>Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge, TN 37831.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN 37831.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge</wicri:cityArea></affiliation></author><author><name sortKey="Guo, Jianjun" sort="Guo, Jianjun" uniqKey="Guo J" first="Jianjun" last="Guo">Jianjun Guo</name><affiliation wicri:level="2"><nlm:affiliation>Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge, TN 37831.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge</wicri:cityArea></affiliation></author><author><name sortKey="Ranjan, Priya" sort="Ranjan, Priya" uniqKey="Ranjan P" first="Priya" last="Ranjan">Priya Ranjan</name><affiliation wicri:level="2"><nlm:affiliation>Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge, TN 37831.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge</wicri:cityArea></affiliation></author><author><name sortKey="Singan, Vasanth" sort="Singan, Vasanth" uniqKey="Singan V" first="Vasanth" last="Singan">Vasanth Singan</name><affiliation wicri:level="2"><nlm:affiliation>U.S. Department of Energy Joint Genome Institute, Walnut Creek, CA 94598.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>U.S. Department of Energy Joint Genome Institute, Walnut Creek</wicri:cityArea></affiliation></author><author><name sortKey="Barry, Kerrie" sort="Barry, Kerrie" uniqKey="Barry K" first="Kerrie" last="Barry">Kerrie Barry</name><affiliation wicri:level="2"><nlm:affiliation>U.S. Department of Energy Joint Genome Institute, Walnut Creek, CA 94598.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>U.S. Department of Energy Joint Genome Institute, Walnut Creek</wicri:cityArea></affiliation></author><author><name sortKey="Schmutz, Jeremy" sort="Schmutz, Jeremy" uniqKey="Schmutz J" first="Jeremy" last="Schmutz">Jeremy Schmutz</name><affiliation wicri:level="2"><nlm:affiliation>U.S. Department of Energy Joint Genome Institute, Walnut Creek, CA 94598.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>U.S. Department of Energy Joint Genome Institute, Walnut Creek</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>HudsonAlpha Institute for Biotechnology, Huntsville, AL 35806.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Alabama</region></placeName><wicri:cityArea>HudsonAlpha Institute for Biotechnology, Huntsville</wicri:cityArea></affiliation></author><author><name sortKey="Weighill, Deborah" sort="Weighill, Deborah" uniqKey="Weighill D" first="Deborah" last="Weighill">Deborah Weighill</name><affiliation wicri:level="2"><nlm:affiliation>Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge, TN 37831.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN 37831.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>The Bredesen Center for Interdisciplinary Research and Graduate Education, University of Tennessee, Knoxville, Knoxville, TN 37996.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>The Bredesen Center for Interdisciplinary Research and Graduate Education, University of Tennessee, Knoxville, Knoxville</wicri:cityArea></affiliation></author><author><name sortKey="Jacobson, Daniel" sort="Jacobson, Daniel" uniqKey="Jacobson D" first="Daniel" last="Jacobson">Daniel Jacobson</name><affiliation wicri:level="2"><nlm:affiliation>Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge, TN 37831.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN 37831.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge</wicri:cityArea></affiliation></author><author><name sortKey="Jawdy, Sara" sort="Jawdy, Sara" uniqKey="Jawdy S" first="Sara" last="Jawdy">Sara Jawdy</name><affiliation wicri:level="2"><nlm:affiliation>Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge, TN 37831.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN 37831.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge</wicri:cityArea></affiliation></author><author><name sortKey="Tuskan, Gerald A" sort="Tuskan, Gerald A" uniqKey="Tuskan G" first="Gerald A" last="Tuskan">Gerald A. Tuskan</name><affiliation wicri:level="2"><nlm:affiliation>Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge, TN 37831.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN 37831.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge</wicri:cityArea></affiliation></author><author><name sortKey="Chen, Jin Gui" sort="Chen, Jin Gui" uniqKey="Chen J" first="Jin-Gui" last="Chen">Jin-Gui Chen</name><affiliation wicri:level="2"><nlm:affiliation>Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge, TN 37831 chenj@ornl.gov mucherow@ornl.gov.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN 37831.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge</wicri:cityArea></affiliation></author><author><name sortKey="Muchero, Wellington" sort="Muchero, Wellington" uniqKey="Muchero W" first="Wellington" last="Muchero">Wellington Muchero</name><affiliation wicri:level="2"><nlm:affiliation>Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge, TN 37831 chenj@ornl.gov mucherow@ornl.gov.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN 37831.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2018">2018</date><idno type="RBID">pubmed:29884614</idno><idno type="pmid">29884614</idno><idno type="doi">10.1534/g3.118.200188</idno><idno type="pmc">PMC6071607</idno><idno type="wicri:Area/Main/Corpus">000D96</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000D96</idno><idno type="wicri:Area/Main/Curation">000D96</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000D96</idno><idno type="wicri:Area/Main/Exploration">000D96</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A Variable Polyglutamine Repeat Affects Subcellular Localization and Regulatory Activity of a <i>Populus</i> ANGUSTIFOLIA Protein.</title><author><name sortKey="Bryan, Anthony C" sort="Bryan, Anthony C" uniqKey="Bryan A" first="Anthony C" last="Bryan">Anthony C. Bryan</name><affiliation wicri:level="2"><nlm:affiliation>Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge, TN 37831.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge</wicri:cityArea></affiliation></author><author><name sortKey="Zhang, Jin" sort="Zhang, Jin" uniqKey="Zhang J" first="Jin" last="Zhang">Jin Zhang</name><affiliation wicri:level="2"><nlm:affiliation>Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge, TN 37831.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN 37831.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge</wicri:cityArea></affiliation></author><author><name sortKey="Guo, Jianjun" sort="Guo, Jianjun" uniqKey="Guo J" first="Jianjun" last="Guo">Jianjun Guo</name><affiliation wicri:level="2"><nlm:affiliation>Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge, TN 37831.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge</wicri:cityArea></affiliation></author><author><name sortKey="Ranjan, Priya" sort="Ranjan, Priya" uniqKey="Ranjan P" first="Priya" last="Ranjan">Priya Ranjan</name><affiliation wicri:level="2"><nlm:affiliation>Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge, TN 37831.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge</wicri:cityArea></affiliation></author><author><name sortKey="Singan, Vasanth" sort="Singan, Vasanth" uniqKey="Singan V" first="Vasanth" last="Singan">Vasanth Singan</name><affiliation wicri:level="2"><nlm:affiliation>U.S. Department of Energy Joint Genome Institute, Walnut Creek, CA 94598.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>U.S. Department of Energy Joint Genome Institute, Walnut Creek</wicri:cityArea></affiliation></author><author><name sortKey="Barry, Kerrie" sort="Barry, Kerrie" uniqKey="Barry K" first="Kerrie" last="Barry">Kerrie Barry</name><affiliation wicri:level="2"><nlm:affiliation>U.S. Department of Energy Joint Genome Institute, Walnut Creek, CA 94598.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>U.S. Department of Energy Joint Genome Institute, Walnut Creek</wicri:cityArea></affiliation></author><author><name sortKey="Schmutz, Jeremy" sort="Schmutz, Jeremy" uniqKey="Schmutz J" first="Jeremy" last="Schmutz">Jeremy Schmutz</name><affiliation wicri:level="2"><nlm:affiliation>U.S. Department of Energy Joint Genome Institute, Walnut Creek, CA 94598.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>U.S. Department of Energy Joint Genome Institute, Walnut Creek</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>HudsonAlpha Institute for Biotechnology, Huntsville, AL 35806.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Alabama</region></placeName><wicri:cityArea>HudsonAlpha Institute for Biotechnology, Huntsville</wicri:cityArea></affiliation></author><author><name sortKey="Weighill, Deborah" sort="Weighill, Deborah" uniqKey="Weighill D" first="Deborah" last="Weighill">Deborah Weighill</name><affiliation wicri:level="2"><nlm:affiliation>Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge, TN 37831.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN 37831.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>The Bredesen Center for Interdisciplinary Research and Graduate Education, University of Tennessee, Knoxville, Knoxville, TN 37996.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>The Bredesen Center for Interdisciplinary Research and Graduate Education, University of Tennessee, Knoxville, Knoxville</wicri:cityArea></affiliation></author><author><name sortKey="Jacobson, Daniel" sort="Jacobson, Daniel" uniqKey="Jacobson D" first="Daniel" last="Jacobson">Daniel Jacobson</name><affiliation wicri:level="2"><nlm:affiliation>Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge, TN 37831.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN 37831.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge</wicri:cityArea></affiliation></author><author><name sortKey="Jawdy, Sara" sort="Jawdy, Sara" uniqKey="Jawdy S" first="Sara" last="Jawdy">Sara Jawdy</name><affiliation wicri:level="2"><nlm:affiliation>Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge, TN 37831.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN 37831.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge</wicri:cityArea></affiliation></author><author><name sortKey="Tuskan, Gerald A" sort="Tuskan, Gerald A" uniqKey="Tuskan G" first="Gerald A" last="Tuskan">Gerald A. Tuskan</name><affiliation wicri:level="2"><nlm:affiliation>Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge, TN 37831.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN 37831.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge</wicri:cityArea></affiliation></author><author><name sortKey="Chen, Jin Gui" sort="Chen, Jin Gui" uniqKey="Chen J" first="Jin-Gui" last="Chen">Jin-Gui Chen</name><affiliation wicri:level="2"><nlm:affiliation>Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge, TN 37831 chenj@ornl.gov mucherow@ornl.gov.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN 37831.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge</wicri:cityArea></affiliation></author><author><name sortKey="Muchero, Wellington" sort="Muchero, Wellington" uniqKey="Muchero W" first="Wellington" last="Muchero">Wellington Muchero</name><affiliation wicri:level="2"><nlm:affiliation>Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge, TN 37831 chenj@ornl.gov mucherow@ornl.gov.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN 37831.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge</wicri:cityArea></affiliation></author></analytic><series><title level="j">G3 (Bethesda, Md.)</title><idno type="eISSN">2160-1836</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Active Transport, Cell Nucleus (MeSH)</term><term>Alleles (MeSH)</term><term>Cell Nucleus (metabolism)</term><term>DNA-Binding Proteins (chemistry)</term><term>DNA-Binding Proteins (metabolism)</term><term>Peptides (chemistry)</term><term>Plant Proteins (chemistry)</term><term>Plant Proteins (metabolism)</term><term>Populus (genetics)</term><term>Populus (metabolism)</term><term>Protein Sorting Signals (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Allèles (MeSH)</term><term>Noyau de la cellule (métabolisme)</term><term>Peptides (composition chimique)</term><term>Populus (génétique)</term><term>Populus (métabolisme)</term><term>Protéines de liaison à l'ADN (composition chimique)</term><term>Protéines de liaison à l'ADN (métabolisme)</term><term>Protéines végétales (composition chimique)</term><term>Protéines végétales (métabolisme)</term><term>Signaux de triage des protéines (MeSH)</term><term>Transport nucléaire actif (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>DNA-Binding Proteins</term><term>Peptides</term><term>Plant Proteins</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Peptides</term><term>Protéines de liaison à l'ADN</term><term>Protéines végétales</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Populus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Populus</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cell Nucleus</term><term>DNA-Binding Proteins</term><term>Plant Proteins</term><term>Populus</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Noyau de la cellule</term><term>Populus</term><term>Protéines de liaison à l'ADN</term><term>Protéines végétales</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Active Transport, Cell Nucleus</term><term>Alleles</term><term>Protein Sorting Signals</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Allèles</term><term>Signaux de triage des protéines</term><term>Transport nucléaire actif</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Polyglutamine (polyQ) stretches have been reported to occur in proteins across many organisms including animals, fungi and plants. Expansion of these repeats has attracted much attention due their associations with numerous human diseases including Huntington's and other neurological maladies. This suggests that the relative length of polyQ stretches is an important modulator of their function. Here, we report the identification of a <i>Populus</i> C-terminus binding protein (CtBP) ANGUSTIFOLIA (<i>PtAN1</i>) which contains a polyQ stretch whose functional relevance had not been established. Analysis of 917 resequenced <i>Populus trichocarpa</i> genotypes revealed three allelic variants at this locus encoding 11-, 13- and 15-glutamine residues. Transient expression assays using <i>Populus</i> leaf mesophyll protoplasts revealed that the 11Q variant exhibited strong nuclear localization whereas the 15Q variant was only found in the cytosol, with the 13Q variant exhibiting localization in both subcellular compartments. We assessed functional implications by evaluating expression changes of putative <i>PtAN1</i> targets in response to overexpression of the three allelic variants and observed allele-specific differences in expression levels of putative targets. Our results provide evidence that variation in polyQ length modulates <i>Pt</i>AN1 function by altering subcellular localization.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29884614</PMID><DateCompleted><Year>2018</Year><Month>11</Month><Day>06</Day></DateCompleted><DateRevised><Year>2019</Year><Month>09</Month><Day>12</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2160-1836</ISSN><JournalIssue CitedMedium="Internet"><Volume>8</Volume><Issue>8</Issue><PubDate><Year>2018</Year><Month>07</Month><Day>31</Day></PubDate></JournalIssue><Title>G3 (Bethesda, Md.)</Title><ISOAbbreviation>G3 (Bethesda)</ISOAbbreviation></Journal><ArticleTitle>A Variable Polyglutamine Repeat Affects Subcellular Localization and Regulatory Activity of a <i>Populus</i> ANGUSTIFOLIA Protein.</ArticleTitle><Pagination><MedlinePgn>2631-2641</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1534/g3.118.200188</ELocationID><Abstract><AbstractText>Polyglutamine (polyQ) stretches have been reported to occur in proteins across many organisms including animals, fungi and plants. Expansion of these repeats has attracted much attention due their associations with numerous human diseases including Huntington's and other neurological maladies. This suggests that the relative length of polyQ stretches is an important modulator of their function. Here, we report the identification of a <i>Populus</i> C-terminus binding protein (CtBP) ANGUSTIFOLIA (<i>PtAN1</i>) which contains a polyQ stretch whose functional relevance had not been established. Analysis of 917 resequenced <i>Populus trichocarpa</i> genotypes revealed three allelic variants at this locus encoding 11-, 13- and 15-glutamine residues. Transient expression assays using <i>Populus</i> leaf mesophyll protoplasts revealed that the 11Q variant exhibited strong nuclear localization whereas the 15Q variant was only found in the cytosol, with the 13Q variant exhibiting localization in both subcellular compartments. We assessed functional implications by evaluating expression changes of putative <i>PtAN1</i> targets in response to overexpression of the three allelic variants and observed allele-specific differences in expression levels of putative targets. Our results provide evidence that variation in polyQ length modulates <i>Pt</i>AN1 function by altering subcellular localization.</AbstractText><CopyrightInformation>Copyright © 2018 Bryan et al.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bryan</LastName><ForeName>Anthony C</ForeName><Initials>AC</Initials><AffiliationInfo><Affiliation>Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge, TN 37831.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Jin</ForeName><Initials>J</Initials><Identifier Source="ORCID">0000-0002-8397-5078</Identifier><AffiliationInfo><Affiliation>Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge, TN 37831.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN 37831.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guo</LastName><ForeName>Jianjun</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge, TN 37831.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ranjan</LastName><ForeName>Priya</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge, TN 37831.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Singan</LastName><ForeName>Vasanth</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>U.S. Department of Energy Joint Genome Institute, Walnut Creek, CA 94598.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Barry</LastName><ForeName>Kerrie</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>U.S. Department of Energy Joint Genome Institute, Walnut Creek, CA 94598.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schmutz</LastName><ForeName>Jeremy</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>U.S. Department of Energy Joint Genome Institute, Walnut Creek, CA 94598.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>HudsonAlpha Institute for Biotechnology, Huntsville, AL 35806.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Weighill</LastName><ForeName>Deborah</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge, TN 37831.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN 37831.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The Bredesen Center for Interdisciplinary Research and Graduate Education, University of Tennessee, Knoxville, Knoxville, TN 37996.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jacobson</LastName><ForeName>Daniel</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge, TN 37831.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN 37831.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jawdy</LastName><ForeName>Sara</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge, TN 37831.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN 37831.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tuskan</LastName><ForeName>Gerald A</ForeName><Initials>GA</Initials><Identifier Source="ORCID">0000-0003-0106-1289</Identifier><AffiliationInfo><Affiliation>Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge, TN 37831.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN 37831.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Jin-Gui</ForeName><Initials>JG</Initials><Identifier Source="ORCID">0000-0002-1752-4201</Identifier><AffiliationInfo><Affiliation>Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge, TN 37831 chenj@ornl.gov mucherow@ornl.gov.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN 37831.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Muchero</LastName><ForeName>Wellington</ForeName><Initials>W</Initials><Identifier Source="ORCID">0000-0002-0200-9856</Identifier><AffiliationInfo><Affiliation>Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge, TN 37831 chenj@ornl.gov mucherow@ornl.gov.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN 37831.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>07</Month><Day>31</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>G3 (Bethesda)</MedlineTA><NlmUniqueID>101566598</NlmUniqueID><ISSNLinking>2160-1836</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004268">DNA-Binding Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010455">Peptides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010940">Plant Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D021382">Protein Sorting Signals</NameOfSubstance></Chemical><Chemical><RegistryNumber>26700-71-0</RegistryNumber><NameOfSubstance UI="C097188">polyglutamine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D021581" MajorTopicYN="N">Active Transport, Cell Nucleus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000483" MajorTopicYN="N">Alleles</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002467" MajorTopicYN="N">Cell Nucleus</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004268" MajorTopicYN="N">DNA-Binding Proteins</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010455" MajorTopicYN="N">Peptides</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010940" MajorTopicYN="N">Plant Proteins</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D032107" MajorTopicYN="N">Populus</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D021382" MajorTopicYN="N">Protein Sorting Signals</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">PolyQ</Keyword><Keyword MajorTopicYN="Y">Populus</Keyword><Keyword MajorTopicYN="Y">cell wall</Keyword><Keyword MajorTopicYN="Y">lignin</Keyword><Keyword MajorTopicYN="Y">subcellular localization</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>6</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2018</Year><Month>11</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>6</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29884614</ArticleId><ArticleId IdType="pii">g3.118.200188</ArticleId><ArticleId IdType="doi">10.1534/g3.118.200188</ArticleId><ArticleId IdType="pmc">PMC6071607</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Proc Biol Sci. 2008 Dec 22;275(1653):2813-21</Citation><ArticleIdList><ArticleId IdType="pubmed">18713722</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Plant Biol. 2013 May 14;13:79</Citation><ArticleIdList><ArticleId IdType="pubmed">23672620</ArticleId></ArticleIdList></Reference><Reference><Citation>Plant J. 2004 Mar;37(6):914-39</Citation><ArticleIdList><ArticleId IdType="pubmed">14996223</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Genomics. 2010 Nov 23;11:654</Citation><ArticleIdList><ArticleId IdType="pubmed">21092319</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2007 Aug 08;2(8):e718</Citation><ArticleIdList><ArticleId IdType="pubmed">17684564</ArticleId></ArticleIdList></Reference><Reference><Citation>Genet Epidemiol. 2014 Nov;38(7):610-21</Citation><ArticleIdList><ArticleId IdType="pubmed">25168954</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Genet. 2010 Apr;11(4):247-58</Citation><ArticleIdList><ArticleId IdType="pubmed">20177426</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 1994 Feb 11;263(5148):808-11</Citation><ArticleIdList><ArticleId IdType="pubmed">8303297</ArticleId></ArticleIdList></Reference><Reference><Citation>Genetics. 2014 Oct;198(2):747-54</Citation><ArticleIdList><ArticleId IdType="pubmed">25116137</ArticleId></ArticleIdList></Reference><Reference><Citation>Hum Mol Genet. 2004 Aug 15;13(16):1677-92</Citation><ArticleIdList><ArticleId IdType="pubmed">15198988</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Biol Sci. 1992 Oct 22;250(1327):43-9</Citation><ArticleIdList><ArticleId IdType="pubmed">1361061</ArticleId></ArticleIdList></Reference><Reference><Citation>Genome Biol. 2013 Apr 25;14(4):R36</Citation><ArticleIdList><ArticleId IdType="pubmed">23618408</ArticleId></ArticleIdList></Reference><Reference><Citation>Methods. 2001 Dec;25(4):402-8</Citation><ArticleIdList><ArticleId IdType="pubmed">11846609</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 1996 Feb 20;93(4):1560-5</Citation><ArticleIdList><ArticleId IdType="pubmed">8643671</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Biotechnol. 2011 Dec 18;30(1):61-8</Citation><ArticleIdList><ArticleId IdType="pubmed">22178994</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2001 Dec 21;276(51):48262-8</Citation><ArticleIdList><ArticleId IdType="pubmed">11590170</ArticleId></ArticleIdList></Reference><Reference><Citation>Genome Res. 2003 Nov;13(11):2498-504</Citation><ArticleIdList><ArticleId IdType="pubmed">14597658</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2012;7(4):e35140</Citation><ArticleIdList><ArticleId IdType="pubmed">22506071</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Biol Evol. 2011 Oct;28(10):2731-9</Citation><ArticleIdList><ArticleId IdType="pubmed">21546353</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Ecol. 2007 Nov;16(22):4867-80</Citation><ArticleIdList><ArticleId IdType="pubmed">17927702</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19363-7</Citation><ArticleIdList><ArticleId IdType="pubmed">23129635</ArticleId></ArticleIdList></Reference><Reference><Citation>Hum Mol Genet. 2003 Jun 15;12(12):1377-91</Citation><ArticleIdList><ArticleId IdType="pubmed">12783846</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 1991 Jul 4;352(6330):77-9</Citation><ArticleIdList><ArticleId IdType="pubmed">2062380</ArticleId></ArticleIdList></Reference><Reference><Citation>Genetics. 2010 Nov;186(3):1033-44</Citation><ArticleIdList><ArticleId IdType="pubmed">20805554</ArticleId></ArticleIdList></Reference><Reference><Citation>Plant J. 2006 Nov;48(4):592-605</Citation><ArticleIdList><ArticleId IdType="pubmed">17059405</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Ecol. 2009 Jun;18(11):2444-56</Citation><ArticleIdList><ArticleId IdType="pubmed">19457200</ArticleId></ArticleIdList></Reference><Reference><Citation>EMBO J. 2002 Mar 15;21(6):1267-79</Citation><ArticleIdList><ArticleId IdType="pubmed">11889033</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Genomics. 2007 May 22;8:126</Citation><ArticleIdList><ArticleId IdType="pubmed">17519034</ArticleId></ArticleIdList></Reference><Reference><Citation>Nucleic Acids Res. 2012 Jan;40(Database issue):D1178-86</Citation><ArticleIdList><ArticleId IdType="pubmed">22110026</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell. 1993 Mar 26;72(6):971-83</Citation><ArticleIdList><ArticleId IdType="pubmed">8458085</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Cell. 2015 Aug 20;59(4):615-27</Citation><ArticleIdList><ArticleId IdType="pubmed">26257283</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Genomics. 2013 Feb 02;14:76</Citation><ArticleIdList><ArticleId IdType="pubmed">23374135</ArticleId></ArticleIdList></Reference><Reference><Citation>Neuron. 2002 Aug 29;35(5):819-22</Citation><ArticleIdList><ArticleId IdType="pubmed">12372277</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Opin Genet Dev. 2012 Jun;22(3):251-5</Citation><ArticleIdList><ArticleId IdType="pubmed">22284692</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2006 Sep 15;313(5793):1596-604</Citation><ArticleIdList><ArticleId IdType="pubmed">16973872</ArticleId></ArticleIdList></Reference><Reference><Citation>Nucleic Acids Res. 2012 May;40(10):4273-87</Citation><ArticleIdList><ArticleId IdType="pubmed">22287626</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Genet. 2014 Oct;46(10):1089-96</Citation><ArticleIdList><ArticleId IdType="pubmed">25151358</ArticleId></ArticleIdList></Reference><Reference><Citation>Nucleic Acids Res. 2017 Jul 3;45(W1):W122-W129</Citation><ArticleIdList><ArticleId IdType="pubmed">28472432</ArticleId></ArticleIdList></Reference><Reference><Citation>Ann Bot. 2014 May;113(6):967-75</Citation><ArticleIdList><ArticleId IdType="pubmed">24615344</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Opin Plant Biol. 2004 Aug;7(4):465-71</Citation><ArticleIdList><ArticleId IdType="pubmed">15231271</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Genomics. 2015 Jan 23;16:24</Citation><ArticleIdList><ArticleId IdType="pubmed">25613058</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 1998 Feb 27;273(9):5204-10</Citation><ArticleIdList><ArticleId IdType="pubmed">9478975</ArticleId></ArticleIdList></Reference><Reference><Citation>Bioinformatics. 2014 Apr 1;30(7):923-30</Citation><ArticleIdList><ArticleId IdType="pubmed">24227677</ArticleId></ArticleIdList></Reference><Reference><Citation>J Phys Chem B. 2012 Aug 30;116(34):10135-44</Citation><ArticleIdList><ArticleId IdType="pubmed">22849385</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2012;7(9):e44908</Citation><ArticleIdList><ArticleId IdType="pubmed">23028673</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2005 Oct 14;280(41):34908-16</Citation><ArticleIdList><ArticleId IdType="pubmed">16051598</ArticleId></ArticleIdList></Reference><Reference><Citation>Plant J. 2011 Dec;68(5):788-99</Citation><ArticleIdList><ArticleId IdType="pubmed">21801251</ArticleId></ArticleIdList></Reference><Reference><Citation>Plant Cell. 2007 Sep;19(9):2776-92</Citation><ArticleIdList><ArticleId IdType="pubmed">17890373</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Genet. 2005 Oct;6(10):743-55</Citation><ArticleIdList><ArticleId IdType="pubmed">16205714</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Genet. 1993 Jul;4(3):221-6</Citation><ArticleIdList><ArticleId IdType="pubmed">8358429</ArticleId></ArticleIdList></Reference><Reference><Citation>Genome Biol. 2014;15(12):550</Citation><ArticleIdList><ArticleId IdType="pubmed">25516281</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Alabama</li><li>Californie</li><li>Tennessee</li></region></list><tree><country name="États-Unis"><region name="Tennessee"><name sortKey="Bryan, Anthony C" sort="Bryan, Anthony C" uniqKey="Bryan A" first="Anthony C" last="Bryan">Anthony C. Bryan</name></region><name sortKey="Barry, Kerrie" sort="Barry, Kerrie" uniqKey="Barry K" first="Kerrie" last="Barry">Kerrie Barry</name><name sortKey="Chen, Jin Gui" sort="Chen, Jin Gui" uniqKey="Chen J" first="Jin-Gui" last="Chen">Jin-Gui Chen</name><name sortKey="Chen, Jin Gui" sort="Chen, Jin Gui" uniqKey="Chen J" first="Jin-Gui" last="Chen">Jin-Gui Chen</name><name sortKey="Guo, Jianjun" sort="Guo, Jianjun" uniqKey="Guo J" first="Jianjun" last="Guo">Jianjun Guo</name><name sortKey="Jacobson, Daniel" sort="Jacobson, Daniel" uniqKey="Jacobson D" first="Daniel" last="Jacobson">Daniel Jacobson</name><name sortKey="Jacobson, Daniel" sort="Jacobson, Daniel" uniqKey="Jacobson D" first="Daniel" last="Jacobson">Daniel Jacobson</name><name sortKey="Jawdy, Sara" sort="Jawdy, Sara" uniqKey="Jawdy S" first="Sara" last="Jawdy">Sara Jawdy</name><name sortKey="Jawdy, Sara" sort="Jawdy, Sara" uniqKey="Jawdy S" first="Sara" last="Jawdy">Sara Jawdy</name><name sortKey="Muchero, Wellington" sort="Muchero, Wellington" uniqKey="Muchero W" first="Wellington" last="Muchero">Wellington Muchero</name><name sortKey="Muchero, Wellington" sort="Muchero, Wellington" uniqKey="Muchero W" first="Wellington" last="Muchero">Wellington Muchero</name><name sortKey="Ranjan, Priya" sort="Ranjan, Priya" uniqKey="Ranjan P" first="Priya" last="Ranjan">Priya Ranjan</name><name sortKey="Schmutz, Jeremy" sort="Schmutz, Jeremy" uniqKey="Schmutz J" first="Jeremy" last="Schmutz">Jeremy Schmutz</name><name sortKey="Schmutz, Jeremy" sort="Schmutz, Jeremy" uniqKey="Schmutz J" first="Jeremy" last="Schmutz">Jeremy Schmutz</name><name sortKey="Singan, Vasanth" sort="Singan, Vasanth" uniqKey="Singan V" first="Vasanth" last="Singan">Vasanth Singan</name><name sortKey="Tuskan, Gerald A" sort="Tuskan, Gerald A" uniqKey="Tuskan G" first="Gerald A" last="Tuskan">Gerald A. Tuskan</name><name sortKey="Tuskan, Gerald A" sort="Tuskan, Gerald A" uniqKey="Tuskan G" first="Gerald A" last="Tuskan">Gerald A. Tuskan</name><name sortKey="Weighill, Deborah" sort="Weighill, Deborah" uniqKey="Weighill D" first="Deborah" last="Weighill">Deborah Weighill</name><name sortKey="Weighill, Deborah" sort="Weighill, Deborah" uniqKey="Weighill D" first="Deborah" last="Weighill">Deborah Weighill</name><name sortKey="Weighill, Deborah" sort="Weighill, Deborah" uniqKey="Weighill D" first="Deborah" last="Weighill">Deborah Weighill</name><name sortKey="Zhang, Jin" sort="Zhang, Jin" uniqKey="Zhang J" first="Jin" last="Zhang">Jin Zhang</name><name sortKey="Zhang, Jin" sort="Zhang, Jin" uniqKey="Zhang J" first="Jin" last="Zhang">Jin Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Bois/explor/PoplarV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001083 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001083 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Bois
|area= PoplarV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:29884614
|texte= A Variable Polyglutamine Repeat Affects Subcellular Localization and Regulatory Activity of a Populus ANGUSTIFOLIA Protein.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:29884614" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a PoplarV1
| This area was generated with Dilib version V0.6.37. |  |